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Transport Scotland say more than £500,000 is being invested in essential maintenance on the Lanarkshire stretch of the road.
The repairs, which are being carried out by Scotland TranServ, are being staggered over a number of weeks to help minimise disruption.
They will result in an improved surface between junction 12, Millbank and junction 6, Hamilton.
The programme has already addressed defects at junctions 9 and 10 and the next stage will begin later at junction 12.
Scotland TranServ say everything possible is being done to minimise disruption and maintain safety, and a combination of closures and contraflows will be used.
The plans for this weekend are:
Thursday and Friday, March 3 and 4 – M74 northbound will close between 8pm and 6am each night to allow the installation of the contraflow. Traffic should leave the M74 at junction 12 to join the B7078 before going back onto the M74 at junction 9.
Saturday, March 5 – The southbound on-slip at junction 10 will be closed and traffic will be diverted to join the M74 at junction 12.
Sunday, March 6 – The southbound on-slip at junction 10 will remain closed and traffic will be diverted to join the M74 at junction 12. The M74 northbound will close at 8pm on completion of the repairs to allow the contraflow to be removed.
Andy Fraser, operating company representative for Scotland TranServ, said: “This is one of the most important roads in Scotland, and we hope that following our programme of work, commuters, tourists and freight drivers will benefit from these improvements for many years to come.
“We are doing all we can to keep disruption as a result of the work to a minimum and motorists can keep up to date with real time traffic information by visiting the Traffic Scotland website and following their Twitter feed.
“Advanced warning signs will also be in place to inform motorists that work is underway.”